The protective effect of Zingiber officinale L. extract on kidney tissues and blood factors of kidney functions after the damage caused by Azathioprine

The most commonly prescribed medication for autoimmune disorders is Azathioprine (AZA), which negatively affects renal function and tissue structure. aim of this work was to measure the therapeutic impact Zingiber officinale L. extract (ZOE) on improving structure AZA-induced damaged tissue.
 Methods: 70 rats with a weight range 200±10 g an age 95±5 days were chosen experimental study. animals grouped into seven groups ten, two receiving no treatment (control groups) five ZOE, AZA, “AZA + ZOE”, normal saline. AZA given intraperitoneally, ZOE by gavage (i.e., nasogastric tube) 21 days. Finally, urea, uric acid, creatinine parameters, diameter some key or important parts kidney measured in different animal groups.
 Results: it found that use (50 mg/kg) increased serum urea concentrations, blood acid comparison group control (P<0.05). Whereas injecting (200 induces considerable decrease concentration compounds mentioned above as compared Furthermore, findings revealed caused inflammation destruction, while improved, restored, recovered affected Conclusion: according research findings, can be decided has protective owing its strong antioxidant attributes ability inhibit free radicals produced azathioprine